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Effects of Cannabidiol Interactions with CYP2R1, CYP27B1, CYP24A1, and Vitamin D(3) Receptors on Spatial Memory, Pain, Inflammation, and Aging in Vitamin D(3) Deficiency Diet-Induced Rats.
Trivedi MK, Mondal S, Gangwar M, Jana S. Trivedi MK, et al. Cannabis Cannabinoid Res. 2023 Dec;8(6):1019-1029. doi: 10.1089/can.2021.0240. Epub 2022 Apr 19. Cannabis Cannabinoid Res. 2023. PMID: 35443806
Materials and Methods: Cytochrome P-450 enzymes were analyzed by RT-PCR method and others biomarkers by enzyme-linked immunosorbent assay. Results: CYP2R1 and CYP27B1-mRNA were significantly increased by 39.29 and 38.37%, respectively, while; CYP24A1-mRNA was significantly …
Materials and Methods: Cytochrome P-450 enzymes were analyzed by RT-PCR method and others biomarkers by enzyme-linked immunosorbent assay. R …
Vitamin D deficiency and genetic polymorphisms of vitamin D-associated genes in Parkinson's disease.
Pal R, Choudhury S, Kumar H, Dey S, Das N, Basu BR. Pal R, et al. Eur J Neurosci. 2023 Sep;58(5):3362-3377. doi: 10.1111/ejn.16098. Epub 2023 Jul 24. Eur J Neurosci. 2023. PMID: 37485791 Review.
Specifically, explicating the effect of VDD and genetic polymorphisms of vitamin D-associated genes in PD, like VDR (vitamin D receptor) or GC (vitamin D binding protein) may aid the process along with polymorphisms of vitamin D metabolising genes (e.g., CYP2R1 and CYP27A1 …
Specifically, explicating the effect of VDD and genetic polymorphisms of vitamin D-associated genes in PD, like VDR (vitamin D receptor) or …
Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus.
Barchetta I, Carotti S, Labbadia G, Gentilucci UV, Muda AO, Angelico F, Silecchia G, Leonetti F, Fraioli A, Picardi A, Morini S, Cavallo MG. Barchetta I, et al. Hepatology. 2012 Dec;56(6):2180-7. doi: 10.1002/hep.25930. Hepatology. 2012. PMID: 22753133

Parenchymal and inflammatory cells from liver biopsies of patients with NASH and CHC expressed VDR, CYP2R1, and CYP27A1. In NASH patients, VDR expression on cholangiocytes was inversely correlated with steatosis severity (P < 0.02), lobular inflammation (P < 0

…
Parenchymal and inflammatory cells from liver biopsies of patients with NASH and CHC expressed VDR, CYP2R1, and CYP27A1. In NASH pati …
Activation of vitamin D in the gingival epithelium and its role in gingival inflammation and alveolar bone loss.
Menzel LP, Ruddick W, Chowdhury MH, Brice DC, Clance R, Porcelli E, Ryan LK, Lee J, Yilmaz Ö, Kirkwood KL, McMahon L, Tran A, Diamond G. Menzel LP, et al. J Periodontal Res. 2019 Aug;54(4):444-452. doi: 10.1111/jre.12646. Epub 2019 Feb 25. J Periodontal Res. 2019. PMID: 30802957 Free PMC article.
RESULTS: Dietary restriction of vitamin D led to alveolar bone loss and increased inflammation in the gingiva in the mouse model. In primary human GEC and established human cell lines, treatment of GEC with 1,25(OH)(2) D(3) inhibited the intracellular growth of P. gingival …
RESULTS: Dietary restriction of vitamin D led to alveolar bone loss and increased inflammation in the gingiva in the mouse model. In …
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.
Wang M, Zhang R, Wang M, Zhang L, Ding Y, Tang Z, Wang H, Zhang W, Chen Y, Wang J. Wang M, et al. Front Genet. 2021 Aug 16;12:717533. doi: 10.3389/fgene.2021.717533. eCollection 2021. Front Genet. 2021. PMID: 34484304 Free PMC article.
BACKGROUND: Previous studies have highlighted the important role of vitamin D and calcium pathway genes in immune modulation, cell differentiation and proliferation, and inflammation regulation, all closely implicated in the pathogenesis of non-alcoholic fatty liver diseas …
BACKGROUND: Previous studies have highlighted the important role of vitamin D and calcium pathway genes in immune modulation, cell different …
The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases.
Inoue N, Watanabe M, Ishido N, Katsumata Y, Kagawa T, Hidaka Y, Iwatani Y. Inoue N, et al. Clin Exp Immunol. 2014 Nov;178(2):262-9. doi: 10.1111/cei.12420. Clin Exp Immunol. 2014. PMID: 25046415 Free PMC article.
The frequency of the Gc1Gc1 genotype for the GC polymorphism and the AG genotype for the CYP2R1 polymorphism were lower in intractable GD than in GD in remission (P = 0.0093 and 0.0268, respectively). In conclusion, genetic differences in the VDR gene may be involved in th …
The frequency of the Gc1Gc1 genotype for the GC polymorphism and the AG genotype for the CYP2R1 polymorphism were lower in intractabl …
Vitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity in rat.
El-Boshy M, BaSalamah MA, Ahmad J, Idris S, Mahbub A, Abdelghany AH, Almaimani RA, Almasmoum H, Ghaith MM, Elzubier M, Refaat B. El-Boshy M, et al. Free Radic Biol Med. 2019 Sep;141:310-321. doi: 10.1016/j.freeradbiomed.2019.06.030. Epub 2019 Jun 27. Free Radic Biol Med. 2019. PMID: 31255668
Acute paracetamol (APAP) toxicity is a leading cause of liver, and less commonly renal, injuries through oxidative stress and inflammation. Albeit vitamin D (VD) is a well-known anti-oxidant and anti-inflammatory hormone, there is no report on its potential protective/ther …
Acute paracetamol (APAP) toxicity is a leading cause of liver, and less commonly renal, injuries through oxidative stress and inflammatio …
Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.
Slominski AT, Brożyna AA, Zmijewski MA, Jóźwicki W, Jetten AM, Mason RS, Tuckey RC, Elmets CA. Slominski AT, et al. Lab Invest. 2017 Jun;97(6):706-724. doi: 10.1038/labinvest.2017.3. Epub 2017 Feb 20. Lab Invest. 2017. PMID: 28218743 Free PMC article. Review.
Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)(2)D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, …
Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25( …
Fluorene-9-bisphenol exposure decreases locomotor activity and induces lipid-metabolism disorders by impairing fatty acid oxidation in zebrafish.
Zhang S, Xu Y, Zhang S, Zhao C, Feng D, Feng X. Zhang S, et al. Life Sci. 2022 Apr 1;294:120379. doi: 10.1016/j.lfs.2022.120379. Epub 2022 Feb 5. Life Sci. 2022. PMID: 35134438
KEY FINDINGS: We found that high concentration (100 nmol/L) BHPF caused retarded growth, mild lipid accumulation and reduced the locomotive activity of zebrafish larvae, accompanied by a decrease in endogenous cortisol level. At the same time, it caused the full activation of …
KEY FINDINGS: We found that high concentration (100 nmol/L) BHPF caused retarded growth, mild lipid accumulation and reduced the locomotive …
16 results